2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1751E
    Quinidine polygalacturonate
    		Inhibitor
    Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research.
    Quinidine polygalacturonate
  • HY-158379
    Antiparasitic agent-22
    		Inhibitor
    Antiparasitic agent-22 (Compound 24) is a pan antiparasitic agent, that inhibits T. Brucei, L. infantum, L. tropica promastigotes (IC50 of 2.41, 5.95, 8.98 μM), L. infantum amastigotes (IC50 of 8.18 μM) and P. falciparum W2 strain (IC50 of 0.155 μM). Antiparasitic agent-22 exhibits low cytotoxicity against THP1, with CC50 of 64.16 μM.
    Antiparasitic agent-22
  • HY-149882
    Antimalarial agent 27
    		Inhibitor
    Antimalarial agent 27 (compound 11a) is an antimalarial agent, potently targeting to P.falciparum (IC50=0.37 μM). Antimalarial agent 27 acts function via P.falciparum DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibition (IC50=0.11 μM).
    Antimalarial agent 27
  • HY-148429
    Antimalarial agent 17
    		Inhibitor
    Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides.
    Antimalarial agent 17
  • HY-155845
    Antileishmanial agent-21
    		Inhibitor
    Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM.
    Antileishmanial agent-21
  • HY-125326
    Spinosyn D
    		Inhibitor 99.00%
    Spinosyn D is one of the major components of Spinosad (HY-138800). Spinosad is a natural pesticide that shows biological activity against a range of insects including Lepidoptera.
    Spinosyn D
  • HY-B0357B
    Diclazuril sodium
    		Inhibitor
    Diclazuril sodium (R-64433 sodium) is an anticoccidial agent active in preventing parasitic contamination of livestock and poultry feed. Evaluation of the efficacy of Diclazuril sodium in the treatment of Eimeria infection showed poor performance in sustained levels of oocyst excretion compared with controls. Diclazuril sodium has a significant impact on the pathological effects of young animals in clinical applications.
    Diclazuril sodium
  • HY-136307S
    Tizoxanide-d4 glucuronide
    		Inhibitor
    Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum.
    Tizoxanide-d<sub>4</sub> glucuronide
  • HY-151133
    Antiparasitic agent-9
    		Inhibitor
    Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite.
    Antiparasitic agent-9
  • HY-132931
    TCMDC-125457
    		Modulator
    TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
    TCMDC-125457
  • HY-N0716BR
    Berberine sulfate (Standard)
    Berberine (sulfate) (Standard) is the analytical standard of Berberine (sulfate). This product is intended for research and analytical applications. Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability[1][2].
    Berberine sulfate (Standard)
  • HY-17594R
    Oxyclozanide (Standard)
    		Inhibitor
    Oxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity.
    Oxyclozanide (Standard)
  • HY-126640
    Phomoxanthone A
    		Inhibitor
    Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC50 is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC50 is 0.99, 0.51 and 1.4 µg/mL, respectively.
    Phomoxanthone A
  • HY-151148
    Trypanothione synthetase-IN-1
    Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S.
    Trypanothione synthetase-IN-1
  • HY-155399
    Antitrypanosomal agent 16
    Antitrypanosomal agent 16 is a trypanocide with IC50 of 0.04μM in T. congolense strain IL3000.
    Antitrypanosomal agent 16
  • HY-123601
    DHQZ 36
    		Inhibitor
    DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity.
    DHQZ 36
  • HY-N0193S
    Artesunate-d3
    		Inhibitor
    Artesunate-d3 is the deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
    Artesunate-d<sub>3</sub>
  • HY-169507
    Anthelvencin A
    		Inhibitor
    Anthelvencin A is a pyrrolamide metabolite with moderate antibacterial and anthelmintic activities.
    Anthelvencin A
  • HY-N29777
    Cabraleahydroxylactone
    		Inhibitor
    Cabraleahydroxylactone is a dammarane triterpenoid with antimycobacterial activity against Mycobacterium tuberculosis.
    Cabraleahydroxylactone
  • HY-147940
    TbPTR1 inhibitor 1
    		Inhibitor
    TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM).
    TbPTR1 inhibitor 1
Parasite Isoform Comparison

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